• Internal medicine · Jun 2020

    Case Reports

    An Adult Case of Generalized Convulsions Caused by the Ingestion of Ginkgo biloba Seeds with Alcohol.

    • Fumika Azuma, Kazuya Nokura, Tetsuharu Kako, Daisuke Kobayashi, Teruki Yoshimura, and Keiji Wada.
    • Department of Neurology, Fujita Health University, Bantane Hospital, Japan.
    • Intern. Med. 2020 Jun 15; 59 (12): 1555-1558.

    AbstractA 64-year-old woman developed symptoms of vomiting and tonic-clonic convulsions 9.5 h after eating 50 roasted Ginkgo biloba seeds with 100 g of alcohol. The intravenous administration of pyridoxal phosphate effectively improved the symptoms. Blood samples were collected and stored over 35 h. The assessment of 4'-O-methylpyridoxine and vitamin B6 vitamers indicated high levels of both, but the pyridoxal phosphate levels were low during the acute stage. These results suggest that 4'-O-methylpyridoxine inhibits the transformation of vitamin B6 analogues to the active form, pyridoxal phosphate. In our case, alcohol may have extended the period until ginkgo intoxication appeared.

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