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- Seiji Noda, Ayaka Maeda, Yoji Komiya, and Makoto Soejima.
- Department of Rheumatology, Ome General Municipal Hospital, Japan.
- Intern. Med. 2020 Oct 1; 59 (19): 2423-2425.
AbstractPropionibacterium acnes (P. acnes) is a commensal bacterium indigenous to the skin. Previous reports have suggested that infection with P. acnes causes sarcoidosis, a systemic granulomatous disease. We present the case of a 63-year-old woman who developed subcutaneous nodules. A skin biopsy revealed necrotizing vasculitis and noncaseating granulomas, which are characteristic of sarcoidosis. Immunohistostaining revealed a P. acnes skin infection, which led to the diagnosis of sarcoidosis. Minocycline treatment resolved the infection and improved the patient's symptoms. We herein report a case in which immunohistochemistry was useful in the diagnosis of sarcoidosis.
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