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Case Reports
Fulminant Hepatitis due to de novo Hepatitis B after Cord Blood Transplantation Rescued by Medical Treatment.
- Tomoya Sano, Norio Akuta, Yoshiyuki Suzuki, Kayoko Kasuya, Shunichiro Fujiyama, Yusuke Kawamura, Hitomi Sezaki, Tetsuya Hosaka, Satoshi Saitoh, Masahiro Kobayashi, Fumitaka Suzuki, Mariko Kobayashi, Yasuji Arase, Kenji Ikeda, and Hiromitsu Kumada.
- Department of Hepatology, Toranomon Hospital, Japan.
- Intern. Med. 2020 Jan 1; 59 (12): 1519-1524.
AbstractA 53-year-old man presented with fulminant hepatitis due to de novo hepatitis B. He had been diagnosed previously with adult T-cell leukemia (ATL) and previously resolved hepatitis B virus infection. The ATL had been treated with cord blood transplantation (CBT). He developed fulminant hepatitis 18 months after CBT, 15 months after the withdrawal of immunosuppressants, and 10 months after vitreous injections of methotrexate for ATL-related retinal infiltration. The aggressive medical protocol included entecavir, prednisolone, plasma exchange, hemodialysis, and bilirubin adsorption. We herein report successful medical treatment for fulminant de novo hepatitis B in a patient considered unsuitable for liver transplantation.
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