• Medicine · Jun 2020

    Meta Analysis

    The brain structure and function alterations in tension-type headache: A protocol for systematic review and meta analysis.

    • Jun Zhou, Shirui Cheng, Han Yang, Lei Lan, Yijia Chen, Guixing Xu, Zihan Yin, Zhengjie Li, and Mailan Liu.
    • The Acupuncture and Tuina College, the 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan.
    • Medicine (Baltimore). 2020 Jun 12; 99 (24): e20411e20411.

    ObjectiveThe aim of this systematic review and meta-analysis is to improve the understanding of the pathophysiology of tension-type headache (TTH), as well as propose avenues for future neuroimaging studies of TTH.MethodsFrom the inception dates to May 1, 2020, a systematic literature will search in Medline (Ovid SP), Embase (Ovid SP), Cochrane Central Register of Controlled Trials, Web of Science, and 4 Chinese databases without limitation on language or publication. Additionally, International Clinical Trials Registry Platform , reference lists, and relevant gray literatures will be searched. After screening of eligible references, included studies will be determined according to included criteria, and then data extraction and a methodological quality assessment with a customized checklist will be conducted. Each process will be independently implemented by 2 reviewers, any disagreement will be resolved by consensus to the third researcher. If the extracted data is feasible, anisotropic effect-size version of signed differential mapping will be conducted to perform the meta-analysis of the structural and functional brain alterations in TTH patients.

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