• Shu-Wen Guo, Chang-Fei Dai, Liang Yu, and Xiong-Fei Zhao.
• Department of Neurology-Neuroelectrophysiology, Cardio-Crebrovascular Disease Hospital of Meishan, Meishan, Sichuan.
• Medicine (Baltimore). 2020 Jun 12; 99 (24): e20589.

BackgroundThis study will explore the effectiveness and safety of respiratory muscle training therapy (RMTT) for the treatment of patients with obstructive sleep apnea syndrome (OSAS) after stroke.MethodsIn this study, we will systematically and comprehensively search Cochrane Library, PubMed, EMBASE, WANGFANG, VIP, Chinese Biomedical Literature Database, and China National Knowledge Infrastructure for relevant literature from their inception to March 1, 2020 without any limitations to language and publication status. We will consider any randomized controlled trials focusing on the effectiveness and safety of RMTT for the treatment of patients with OSAS after stroke. The study quality will be checked using Cochrane risk of bias tool, and statistical analysis will be performed utilizing RevMan 5.3 software.ResultsThis study will summarize and synthesize the current evidence of RMTT for the treatment of patients with OSAS following stroke.ConclusionThe findings of this study will assess the present evidence for the benefits and harms of RMTT for treating OSAS after stroke, and will inform clinical practice and future research.Prospero Registration NumberPROSPERO CRD42020170355.

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