• Lei Zhang, Ningbo Lei, Ruilong Chang, Chenxu Yang, Qiang Li, Ning Zuo, and Yubiao Gu.
• The Third Department of Articular Bone, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou, China.
• Medicine (Baltimore). 2020 Jun 12; 99 (24): e20689e20689.

BackgroundThe reduced range of motion and pain are the most characteristic clinical features of osteoarthritis (OA). Hyaluronic acid (HA), which is one of the infiltrative therapies for OA treatment, and polynucleotides (PNs), which is a DNA-derived macromolecule favored cell growth and collagen production, are an ongoing debate in clinical effectiveness.MethodsWe plan to perform a systematic review and meta-analysis of randomized clinical trial to evaluate efficacy of intra-articular polynucleotides associated with hyaluronic acid versus hyaluronic acid alone in the treatment of knee osteoarthritis. We will search PubMed, EMBASE, Cochrane Library using a comprehensive strategy. The related conference proceedings and reference lists of the included studies will also be checked to identify additional studies. Two reviewers will screen retrieved records, extract information and assess the risk of bias independently. Stata v15.1 software will be used to conduct data synthesis.ResultsThis study will be submitted to a peer-reviewed journal for publication.ConclusionWe hope it will provide a relatively comprehensive reference for clinical practice and future relevant clinical trials.Ethics And DisseminationEthics approval and patient consent are not required, as this study is a systematic review and meta-analysis.Prospero Registration NumberCRD42020167678.

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