• Guocai Chen, Yingxin Guan, Xiangling Ye, Guoqian Chen, Jianping Du, Wengang Liu, Chuanxi Zhao, Nan Yao, and Xuemeng Xu.
• The Fifth Clinical Medical School, Guangzhou University of Chinese Medicine.
• Medicine (Baltimore). 2020 Jun 12; 99 (24): e20697.

BackgroundPrimary osteoporosis (POP) is one of the most common orthopedic diseases with a high risk of fracture. Effective treatment of POP is of great significance to reduce the rate of disability and improve the quality of life. Bushen qianggu (BSQG) is a classical method of TCM in treating POP. However, there is no systematic review related to BSQG for POP. The purpose of this study is to provide a comprehensive and reliable evaluation of the clinical evidence of BSQG in the treatment of POP.Methods And AnalysisRelevant randomized controlled trial literature evaluating the effect of BSQG on patients with POP will be obtained by searching the PubMed, Embase, MEDLINE, Cochrane Library Central Register of Controlled Trials, China national knowledge infrastructure database, Wan fang database, Chongqing VIP information, and SinoMed from their inception to May 2020. Two researchers will select and evaluate qualified studies independently. The bone mineral density value and the incidence of fractures will be accepted as the primary outcomes. The meta-analyses will be performed by using the RevMan 5.3.ResultsThis study will provide a comprehensive evaluation of the efficacy and safety of BSQG method for patients with POP.ConclusionThe conclusion of our systematic review will provide evidence to judge whether BSQG is an effective intervention for patients with POP.Trial Registration Number10.17605/OSF.IO/ZMX3W.

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