• Jan Holsheimer and Jan R Buitenweg.
• Institute for Technical Medicine (MIRA), University of Twente, Enschede, The Netherlands.
• Neuromodulation. 2015 Apr 1;18(3):161-70; discussion 170.

ObjectivesThe aim of this review is to make specialists in a variety of disciplines familiar with basic aspects of spinal cord stimulation and the role of mathematical modeling in understanding its mechanisms of action and the solution of basic problems.MethodsThe paper is divided into five sections. The content of each section also covers aspects of various disciplines. Most aspects are presented in an unusual way, likely resulting in new viewpoints and further developments in the growing field of neuromodulation.ResultsA special, integrating role is the mathematical modeling of spinal cord stimulation and the simulation studies of various aspects, such as the stimulation in axial low-back pain.ConclusionsIn particular the conclusions from several computer simulation studies are relevant and of interest to specialists in many disciplines.© 2015 International Neuromodulation Society.

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