• Hetao Huang, Sicong Huang, Guihong Liang, Lingfeng Zeng, Jianke Pan, Weiyi Yang, Hongyun Chen, Jun Liu, and Biqi Pan.
• Second School of Clinical Medicine, Guangzhou University of Chinese Medicine.
• Medicine (Baltimore). 2020 Jan 1; 99 (4): e18910e18910.

BackgroundKnee osteoarthritis (KOA) is a common disease in the elderly, which seriously reduces the quality of life of patients and increases the social burden. proximal fibula osteotomy (PFO) and high tibial osteotomy (HTO) are effective methods to treat KOA. However, it is not entirely clear which method has the advantage. Therefore, we evaluated the efficacy and safety of HTO and PFO in the treatment of KOA.MethodsRandomized controlled trials from online databases including PubMed, Embase, the Cochrane Library, China National Knowledge Infrastructure, Chinese Scientific Journal Database, Wanfang Data and Chinese Biomedical Literature Database that compared the efficacy of HTO and PFO in the treatment of KOA were retrieved. The main outcomes included hospital for special surgery (HSS) knee scores, knee society knee scoring system (KSS) score, visual analog scale (VAS) knee pain scores, western ontario and McMaster universities osteoarthritis index score, operation time, intraoperative bleeding volume, hospitalization time, complications. The Cochrane risk of bias tool was used to assess methodological quality.ResultsThe literature will provide a high-quality analysis of the current evidence supporting HTO for KOA based on various comprehensive assessments including HSS scores, KSS score, VAS scores, western Ontario and McMaster universities osteoarthritis index score, operation time, intraoperative bleeding volume, hospitalization time, and complications.ConclusionThis proposed systematic review will provide up-to-date evidence to assess the effect of HTO in the treatment for patients with KOA.

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