• Panminerva medica · Sep 2024

    Obesity promotes the global hypomethylation of CD4+ T cells in patients with systemic lupus erythematosus via downregulating DNMT1.

    • Linxin Hou, Shasha Li, and Mengmeng Zhao.
    • Department of Rheumatology and Immunology, Shengjing Hospital of China Medical University, Shenyang, China.
    • Panminerva Med. 2024 Sep 1; 66 (3): 237241237-241.

    BackgroundThe global hypomethylation of CD4+ T cells in systemic lupus erythematosus (SLE) patients has been previously reported. However, potential influencing factors are unclear. This study aimed to uncover the potential influence of obese on hypomethylated CD4+ T cells in SLE patients.MethodsObese SLE patients with Body Mass Index (BMI)>30 (N.=15) and normal weight SLE patients with 18ResultsSLEADI, nRNP and dsDNA levels were higher in obese SLE patients than normal weight cases. SLEADI was positively correlated to BMI in included SLE patients. Compared with normal weight SLE patients, methylation rate of CD4+ T cells was lower in obese patients. DNMT1 was downregulated in obese SLE patients, and its level was negatively correlated to BMI in SLE patients. Consistently, methylation rate of CD4+ T cells and DNMT1 level remained lower in obese SLE mice than those normally fed mice with SLE.ConclusionsHypomethylated CD4+ T cells extensively occur in SLE patients, which are much more pronounced in obese cases. DNMT1 level is found to be negatively correlated to the methylation rate of CD4+ T cells in SLE patients.

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