• Hiroyuki Tsuchie, Makoto Emori, Hiroyuki Nagasawa, Naohisa Miyakoshi, Yasutaka Murahashi, Junya Shimizu, Emi Mizushima, Toshihiko Yamashita, and Yoichi Shimada.
• Department of Orthopedic Surgery, Akita University Graduate School of Medicine, Akita, Japan, tuchikiti@yahoo.co.jp.
• Med Princ Pract. 2019 Jan 1; 28 (5): 425-431.

ObjectivesOsteosarcoma is the most common malignant bone tumor in childhood. Although a poorer prognosis has been described in older patients, few reports have focused solely on primary osteosarcoma. We evaluated the clinical features of elderly patients with primary osteosarcoma.Materials And MethodsNinety-four patients were included in this retrospective study, and we divided them into 2 groups (older patients and younger patients) based on a cut-off age of 40 years. The patients' information, including age, tumor type, location, presence of metastasis, American Joint Committee on Cancer (AJCC) stage, treatment-related factors, local and distant relapse, and outcome, was collected. We compared the clinical courses between the 2 groups in all and only deceased patients.ResultsIn all patients, the frequency of chemotherapy in the older group was significantly lower than in the younger group (p < 0.001), and tumors were more frequent in axial bone in the older patients (p = 0.041). Only in patients with surgical treatment, histological effectiveness after chemotherapy in the older group was lower than in the younger group (p = 0.041). The older patients showed a poorer prognosis (p = 0.031). However, the 5-year overall survival rate in the older patients was more favorable than that in the younger patients only among deceased patients (p =0.032). Only the existence of metastasis affected the prognosis in older patients (p = 0.012).ConclusionPrimary osteosarcoma in elderly patients showed a high incidence of axial bone involvement, a low rate of chemotherapy, and resistance to chemotherapy. Although the final life prognosis is poor, survival may be relatively prolonged.© 2019 The Author(s) Published by S. Karger AG, Basel.

31 keywords...

hide…