• Ester Vendrell Torra, Lluís Force Sanmartín, Goretti Sauca Subias, Elisabet Palomera Fànegas, Pilar Barrufet Barqué, and Josep Anton Capdevila Morell.
• Department of Intensive Care Unit, Hospital de Mataró, Consorci Sanitari del Maresme, Carretera de Cirera, s/n, 08304 Mataró, Barcelona, Spain. Electronic address: evendrell@csdm.cat.
• Med Clin (Barc). 2019 Mar 15; 152 (6): 222-225.

Introduction And ObjectiveWe studied the natural history of patients with chronic stable illnesses that are colonized by Methicillin Resistant Staphylococcus aureus (MRSA). The aim was to determine the persistence colonization 1 year after. Moreover, we intended to disclose factors that predict MRSA persistence.Material And MethodsA multicentric, prospective observational study was designed. Patients from an acute-care hospital and 4 long-term healthcare facilities were included. Demographic, clinical and microbiological data (nasal and skin swabs) were obtained every 3 months during a year. MRSA carriers were decolonized with nasal mupirocin.ResultsAmong the 699 screened patients, 114 MRSA carriers were identified. MRSA carriage persisted in 59.4% of those who completed the follow-up. Baseline factors associated to MRSA persistence were heart failure, comorbidities, antibiotics, and ulcers. At one year: LTHF, underweight, Barthel<60, and ulcers (the two latest were independent predictors). Persistence was not associated to decolonization.ConclusionOur study disclosed a high MRSA persistence rate and identified several associated factors (both at baseline and one year later). This information may be useful to identify individuals at high-risk of being MRSA carriers at hospital admission.Copyright © 2018 Elsevier España, S.L.U. All rights reserved.

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