• Medicina clinica · Sep 2020

    Review

    Atherosclerosis and inflammation. New therapeutic approaches.

    • Juan Pedro-Botet, Elisenda Climent, and David Benaiges.
    • Unidad de Lípidos y Riesgo Vascular, Servicio de Endocrinología y Nutrición, Hospital del Mar, Universidad Autónoma de Barcelona, Barcelona, España. Electronic address: 86620@parcdesalutmar.cat.
    • Med Clin (Barc). 2020 Sep 25; 155 (6): 256-262.

    AbstractThe recognition of atherogenesis as an active process rather than a passive cholesterol storage disease has underlined key inflammatory mechanisms. Hence, innate and adaptive immune responses play an important role in the onset and progression of atherosclerosis. More recently, some clinical studies were designed to address the impact of anti-inflammatory intervention strategies in reducing risk of cardiovascular disease beyond the management of classic risk factors. Therefore, we review first the pathophysiological contribution of inflammation to atherosclerosis and the effect of lipid-lowering drugs on inflammatory biomarkers. Next, we address the effect of classic anti-inflammatory drugs, pharmacological therapies targeting specific inflammatory mediators and vaccines in cardiovascular prevention.Copyright © 2020 Elsevier España, S.L.U. All rights reserved.

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