• Medicina clinica · Feb 2021

    Case Reports

    Serological response to influenza vaccine in patients with autoimmune inflammatory diseases: Results of RIER study.

    • Patricia Richi, María Dolores Martín, Cristina Andreu-Vázquez, Ana Jiménez-Diaz, Martina Steiner, and Santiago Muñoz-Fernández.
    • Servicio de Reumatología, Hospital Universitario Infanta Sofía, San Sebastián de los Reyes, Madrid, España; Facultad de Ciencias Biomédicas y de la Salud, Universidad Europea de Madrid, Villaviciosa de Odón, Madrid, España. Electronic address: patricia.richi@salud.madrid.org.
    • Med Clin (Barc). 2021 Feb 12; 156 (3): 118-122.

    BackgroundInfluenza vaccine is recommended for patients with autoimmune inflammatory diseases (AIID) on biological therapy.ObjectiveTo evaluate whether serological response to Influenza vaccine obtained in patients on biological therapy is similar to that achieved in patients on synthetic disease-modifying anti-rheumatic drugs (DMARDs) and that obtained in healthy controls.MethodsWe designed a cohort study in which patients with AIID, 68 on biological therapy and 46 on synthetic DMARDs, as well as 48 healthy controls, were included and vaccinated during the 2015-2016 influenza season. ELISA was used to measure Influenza antigen (Ag) A and B antibodies, before and after vaccination.ResultsAfter vaccination, 88.24% of patients on biologics, 71.74% of those on synthetic DMARDs and 89.58% of healthy controls, presented detectable antibodies against antigen A, while 42.65% of subjects on biologics, 41.30% of those on DMARDs and 54.17% of healthy subjects were seropositive against Ag B. We did not find statistical differences.ConclusionsIn our study, biological therapy is not associated with worse serological response.Copyright © 2020 Elsevier España, S.L.U. All rights reserved.

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