• Clin Med (Lond) · Jul 2020

    Case Reports

    Polytrauma in a geriatric patient resulting in reactivation of cytomegalovirus infection and secondary cold agglutinin disease-induced haemolytic anaemia.

    • Thomas Stockdale, Tom Hosack, Cameron Griffiths, Amit Kj Mandal, and Constantinos G Missouris.
    • Wexham Park Hospital, Slough, UK.
    • Clin Med (Lond). 2020 Jul 1; 20 (4): 433435433-435.

    AbstractHaemolysis is a rare but serious complication of cytomegalovirus (CMV) infection, described mostly in immunocompromised patients, the pathogenesis of which is yet to be fully elucidated. We describe a case of Coombs-positive haemolytic anaemia in an older Caucasian immunocompetent woman after polytrauma, resulting from suspected reactivation of CMV infection and secondary cold agglutinin disease. Clinicians should consider CMV infection in the differential diagnosis of haemolytic anaemia in immunocompetent older adults who are admitted with significant musculoskeletal trauma. Early treatment with B-cell depletion therapy to halt cold agglutinin production can be life-saving.© Royal College of Physicians 2020. All rights reserved.

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