• T El Jammal, M Gerfaud-Valentin, P Sève, and Y Jamilloux.
• Service de médecine interne, université Claude-Bernard Lyon 1, hôpital de la Croix-Rousse, hospices civils de Lyon, groupement hospitalier Nord, 103, Grande rue de la Croix-Rousse, 69004 Lyon, France. Electronic address: thomas.el-jammal@chu-lyon.fr.
• Rev Med Interne. 2019 Dec 1; 40 (12): 816-825.

AbstractIn the past ten years, the better understanding of the pathophysiological mechanisms underlying inflammatory and autoimmune diseases has led to the emergence of many targeted therapies. Among them, the Janus kinase inhibitors are acting upstream in the inflammatory cascade of several key cytokines in disorders such as rheumatoid arthritis, ulcerative colitis or psoriasis. At the moment, these three diseases represent the only indications validated by the FDA and the EMA of the use of JAK inhibitors apart from hematology. Preclinical data and therapeutic trials indicate their efficacy in other autoimmune or inflammatory conditions, such as lupus, dermatomyositis, ankylosing spondylitis, sarcoidosis and giant cell arteritis. This review provides a summary of current use and advancement of knowledge in the use of JAK inhibitors in pathologies faced by internists.Copyright © 2019. Published by Elsevier Masson SAS.

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