• Rev Assoc Med Bras (1992) · Apr 2020

    miR-125a-5p inhibits cancer stem cells phenotype and epithelial to mesenchymal transition in glioblastoma.

    • Xi-De Zhu, Zhen-Juan Gao, and Guo-Dong Zheng.
    • . Department of Neurosurgery, Linyi People's Hospital, Linyi, 276000, Shandong, China.
    • Rev Assoc Med Bras (1992). 2020 Apr 1; 66 (4): 445-451.

    ObjectiveGlioblastoma (GBM) is a common type of cancer with high mortality. Epithelial to mesenchymal transition (EMT) plays a vital role in the development of glioblastoma. The aim of this study is to evaluate the role of miR-125a-5p in glioblastoma and in the tumorigenesis of chemotherapeutic drug-resistant cancer stem-like cells in brain glioma.MethodsThe role of miR-125a-5p in the regulation of CSCs, EMT, migration, and invasion in glioblastoma was measured in this study.ResultsWe showed the roles of miR-125a-5p in the regulation of CSCs, EMT, migration, and invasion in glioblastoma. miR-125a-5p can inhibit the CSCs phenotype and EMT in glioblastoma cells. In addition, its over-expression can significantly regulate CSCs-associated genes and EMT-associated gene expression in glioblastoma cells.ConclusionsWe concluded that miR-125a-5p is one of the key microRNAs regulating CSCs and EMT programs in glioblastoma. The results suggested that miR-125a-5p might be a novel therapy target for glioblastoma.

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