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- Yu Nakanishi, Kakuhiro Yamaguchi, Yusuke Yoshida, Shinjiro Sakamoto, Yasushi Horimasu, Takeshi Masuda, Taku Nakashima, Shintarou Miyamoto, Hiroshi Iwamoto, Shintaro Hirata, Kazunori Fujitaka, Hironobu Hamada, Eiji Sugiyama, and Noboru Hattori.
- Department of Respiratory Internal Medicine, Hiroshima University Hospital, Japan.
- Intern. Med. 2020 Oct 15; 59 (20): 2553-2558.
AbstractAnti-transcriptional intermediary factor 1γ (anti-TIF1γ) antibody-positive dermatomyositis (DM) is strongly associated with cancer, although the mechanism of action is still unclear. We herein describe the first known case of an 80-year-old woman diagnosed with TIF1γ-positive primary pulmonary lymphoepithelioma-like carcinoma (LELC) coexisting with anti-TIF1γ antibody-positive DM. The diagnosis of LELC can only be made by a surgical lung biopsy, and not by a computed tomography-guided biopsy, because of heavy lymphocytic infiltration. This instructive case reaffirmed the importance of active screening for malignancy in patients with anti-TIF1γ antibody-positive DM. Interestingly, the results also suggested that the strong relationship which exists between anti-TIF1γ antibody-positive DM and cancer is potentially caused by tumor-derived TIF1γ.
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