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- Shusaku Fujimoto, Naohiro Oda, Yusuke Fujioka, Reo Mitani, and Ichiro Takata.
- Department of Internal Medicine, Fukuyama City Hospital, Japan.
- Intern. Med. 2020 Oct 15; 59 (20): 2547-2551.
AbstractPulmonary cryptococcosis develops not only in immunocompromised patients but also in immunocompetent patients. However, lymph node involvement is relatively rare in immunocompetent patients. We herein report the case of an 80-year-old man who was not in an apparent immunocompromised state but was diagnosed with pulmonary cryptococcosis with mediastinal lymphadenopathy. The patient was resistant to fluconazole and voriconazole monotherapy; thus, his lung lesions significantly worsened. He eventually responded well to a combination therapy of amphotericin B and flucytosine, which was administered according to the treatment strategy for disseminated diseases.
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