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- Shinichiro Kawaguchi, Kazuya Sato, Hisashi Oshiro, Ken-Ichi Imadome, and Yoshinobu Kanda.
- Division of Hematology, Department of Medicine, Jichi Medical University, Japan.
- Intern. Med. 2020 Oct 15; 59 (20): 2565-2569.
AbstractWe encountered a patient with multiple myeloma treated with autologous hematopoietic stem cell transplantation (HSCT) who developed repeated episodes of enteritis but regressed spontaneously. An endoscopic examination revealed no abnormalities, but biopsy specimens showed massive infiltration of CD4+ and Epstein-Barr encoding region (EBER+) abnormal lymphocytes in which a high copy number of Epstein Barr virus (EBV) genomes was detected by quantitative polymerase chain reaction (qPCR). EBV infection was exclusively detected in CD4+ T-cells, leading to a diagnosis of EBV-positive CD4+ T-cell lymphoproliferative disorder (LPD). This case suggests that an immediate biopsy and examinations, including qPCR for EBV DNA, should be considered for patients with recurrent enteritis after autologous HSCT, regardless of endoscopic findings.
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