• Edgar Ortiz-Brizuela, Marco Villanueva-Reza, María F González-Lara, Karla M Tamez-Torres, Carla M Román-Montes, Bruno A Díaz-Mejía, Esteban Pérez-García, Antonio Olivas-Martínez, Sandra Rajme-López, Bernardo A Martinez-Guerra, Nereyda A de-León-Cividanes, Oscar A Fernández-García, Lorena Guerrero-Torres, Lorena Torres-González, Fabián A Carrera-Patiño, Ever A Corral-Herrera, Aldo N Hernández-Alemón, Maria de Los Á Tovar-Vargas, Yamile G Serrano-Pinto, Cristian E Espejo-Ortiz, María de la L Morales-Ortega, Óscar A Lozano-Cruz, José L Cárdenas-Fragoso, José de J Vidal-Mayo, Thierry Hernández-Gilsoul, Eduardo Rivero-Sigarroa, Guillermo Domínguez-Cherit, Luz E Cervantes-Villar, Maria Del P Ramos-Cervantes, Violeta Ibarra-González, Juan J Calva-Mercado, Juan G Sierra-Madero, Álvaro López-Íñiguez, Eric Ochoa-Hein, Brenda E Crabtree-Ramírez, Arturo Galindo-Fraga, María de L Guerrero-Almeida, Guillermo M Ruiz-Palacios, Alfonso Gulías-Herrero, José Sifuentes-Osornio, David Kershenobich-Stalnikowitz, and Alfredo Ponce-de-León.
• Department of Infectious Diseases, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
• Rev Invest Clin. 2020 Jan 1; 72 (3): 165-177.

BackgroundRegional information regarding the characteristics of patients with coronavirus disease (COVID)-19 is needed for a better understanding of the pandemic.ObjectiveThe objective of the study to describe the clinical features of COVID-19 patients diagnosed in a tertiary-care center in Mexico City and to assess differences according to the treatment setting (ambulatory vs. hospital) and to the need of intensive care (IC).MethodsWe conducted a prospective cohort, including consecutive patients with COVID-19 from February 26, 2020 to April 11, 2020.ResultsWe identified 309 patients (140 inpatients and 169 outpatients). The median age was 43 years (interquartile range, 33-54), 59.2% men, and 18.6% healthcare workers (12.3% from our center). The median body mass index (BMI) was 29.00 kg/m2 and 39.6% had obesity. Compared to outpatients, inpatients were older, had comorbidities, cough, and dyspnea more frequently. Twenty-nine (20.7%) inpatients required treatment in the IC unit (ICU). History of diabetes (type 1 or 2) and abdominal pain were more common in ICU patients compared to non-ICU patients. ICU patients had higher BMIs, higher respiratory rates, and lower room-air capillary oxygen saturations. ICU patients showed a more severe inflammatory response as assessed by white blood cell count, neutrophil and platelet count, C-reactive protein, ferritin, procalcitonin, and albumin levels. By the end of the study period, 65 inpatients had been discharged because of improvement, 70 continued hospitalized, and five had died.ConclusionsPatients with comorbidities, either middle-age obese or elderly complaining of fever, cough, or dyspnea, were more likely to be admitted. At admission, patients with diabetes, high BMI, and clinical or laboratory findings consistent with a severe inflammatory state were more likely to require IC.Copyright: © 2020 Permanyer.

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