• Hua Luo, Kexin Meng, Junling He, Zujian Hu, Ouou Yang, Tian Lan, Kunlun Su, Huifen Yang, Chenni Zhan, and Haibin Xu.
• Department of Breast Surgery, Hangzhou Hospital of Traditional Chinese Medicine.
• Medicine (Baltimore). 2020 Jun 19; 99 (25): e20278.

RationaleIntracystic papillary breast carcinoma is extremely rare in males with a favorable prognosis. Clinical and mammographic manifestations of IPC are not specific, and no consensus has been reached on its management.Patient ConcernsThree cases of IPC of the breast in male patients who underwent surgery are presented. In each patient, clinical manifestations, radiological appearance, surgical procedures, pathological diagnosis, and prognosis were investigated.DiagnosisUltrasonography showed a complex mass with cystic and nodular solid components in 2 patients and a solid hypoechoic mass in the other 1. Contrast-enhanced ultrasonography(CEUS) was performed for 1 patient demonstrated a solid component of the characteristic enhancement patterns. The final diagnosis of IPC was made after an excisional biopsy.InterventionsA mastectomy with sentinel lymph node mapping was carried out in 2 patients, and it was negative for metastatic disease. The third patient received a mastectomy without an investigation of the axillary lymph node status.OutcomesAll the patients are disease-free during a median follow-up of 67 months (range, 13-120) months.LessonsIt is difficult to diagnose IPC of the male breast before surgery, excisional biopsy is necessary. CEUS can be useful to diagnose IPC in male patients in the preoperative evaluation. Sentinel node biopsy may be considered in patients with IPC associated with DCIS or invasive carcinoma.

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