• Qin-Wei Han, Jin-Ping Wu, Ying Pang, Li-Xia Wu, and Li-Na Yang.
• Department of Obstetrics and Gynecology, 521 Hospital of Norinco Group.
• Medicine (Baltimore). 2020 Jun 19; 99 (25): e20590.

BackgroundThis study aims to assess the efficacy and safety of clomifene citrate (CC) for the treatment of patients with polycystic ovary syndrome (PCOS).MethodsIn this study, we will comprehensively search MEDLINE, EMBASE, The Cochrane Library, Web of Science, CINAHL, ACMD, PsycINFO, and China National Knowledge Infrastructure for original articles published from their inceptions to the January 1, 2020 without language restrictions. All studies will undergo relevance and a design selecting process. Data from qualified studies will be collected by 2 independent authors. Additionally, we will conduct a risk of bias evaluation using a Cochrane risk of bias tool. We will undertake statistical analysis utilizing RevMan 5.3 software.ResultsThis study will summarize the up-to-date evidence to investigate the efficacy and safety of CC for the treatment of patients with PCOS.ConclusionThe findings of this study will provide helpful evidence of CC for the treatment of patients with PCOS, as well as may help develop treatment guidelines.Prospero Registration NumberPROSPERO CRD42020162818.

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