• Jing Hu, Li Ma, and Zeng-Ye Yang.
• Department of Neurology, Ankang People's Hospital, Ankang.
• Medicine (Baltimore). 2020 Jun 26; 99 (26): e20608.

BackgroundThis study aims to assess the efficacy and safety of citalopram for the treatment of patients with post-stroke depression (PSD).MethodsWe will comprehensively search Cochrane Library, PUBEMD, EMBASE, WorldSciNet, Web of Science, VIP Database, CBM database, and China National Knowledge Infrastructure. The search period is limited from the construction of each database to the February 1, 2020. No language and publication status are limited. Two investigators will independently carry out study choosing, data extraction, study methodological quality assessment, and quality of evidence. A third investigator will help to resolve any disagreements between 2 investigators. RevMan 5.3 software will be employed for statistical analysis.ResultsThis study will summarize the up-to-date evidence and synthesize the data to explore the efficacy and safety of citalopram for patients with PSD.ConclusionsThe results of this study may present helpful evidence to determine whether citalopram is an effective management for patients with PSD.Prospero Registration NumberPROSPERO CRD42020171015.

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