• Haitao Fan, Xiuyan Wang, Xiao Yang, Hongshu Zheng, and Shuqiang Feng.
• Medicine (Baltimore). 2020 Jun 26; 99 (26): e20894.

RationaleCouples with male balanced-translocation carriers may experience recurrent pregnancy loss (RPL). Although the expectant management of RPL has developed over many years, genetic counseling for RPL couples with male balanced-translocation carriers remains challenging. Here, we describe the expectant management of 2 male carriers of balanced translocations.Patient ConcernsA 32-year-old and a 28-year-old man presented at the clinic with diagnoses of infertility following spontaneous abortions by their wives.DiagnosisBoth patients had normal semen diagnosed by routine semen analysis and underwent cytogenetic diagnoses.InterventionsFollowing genetic counseling and informed consent, both couples voluntarily chose expectant management with natural conception.OutcomesOne couple experienced 2 natural pregnancies, the first of which ended in spontaneous abortion and the second produced a phenotypically normal infant. The other couple's first pregnancy resulted in a fetus with a balanced translocation confirmed by amniocentesis and cytogenetic analysis.LessonsExpectant management with natural conception may be an alternative to genetic counseling in male balanced-translocation carriers with RPL, especially those who are reluctant to undergo preimplantation diagnosis.

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