• Yequn Chen, Zhiquan Ke, Jiaxin Xiao, Mengyue Lin, Xiru Huang, Chunyin Yan, Shu Ye, and Xuerui Tan.
• Department of Cardiology, First Affiliated Hospital of Shantou University Medical College, China (Y.C., Z.K., J.X., M.L., X.H., C.Y., X.T.).
• Circ Cardiovasc Interv. 2018 Jul 1; 11 (7): e006571.

BackgroundTransradial coronary catheterization is widely used as a diagnostic or interventional procedure for coronary disease. However, it can lead to adverse complications, such as radial artery occlusion. We sought to determine whether preprocedural injection of nitroglycerin at the radial artery puncture site reduces radial artery occlusion.Methods And ResultsA total of 188 patients undergoing transradial coronary catheterization were randomized in a single-blind fashion to receive subcutaneous injection of 0.5 mL 0.1% nitroglycerin or a placebo at the radial artery puncture site. The participants underwent ultrasound examinations of the radial artery before and at 24 hours after the procedure. Of the 188 patients enrolled, 182 completed the study, as the procedure failed in 2 participants in the nitroglycerin-treated group and 4 in the placebo group. Baseline demographic and clinical characteristics were similar between 2 groups. Comparing the radial artery diameters before and after the operation, there was a statistically significant increase in the nitroglycerin-treated group (2.48±0.45 versus 2.45±0.46 mm; P=0.003) but a decrease in the placebo control group (2.41±0.50 versus 2.46±0.49 mm; P<0.001). Importantly, the incidence of radial arterial occlusion was substantially lower in the nitroglycerin-treated group than in the placebo control group (5.4% versus 14.4%; P=0.04). There was not significant difference in other complications (forearm hematoma and radial artery pseudoaneurysm, respectively), and there was no incidence of cause hypotension or an intolerable headache.ConclusionsSubcutaneous injection of nitroglycerin at the radial artery puncture site dilates the radial artery and reduces the incidence of early radial artery occlusion post-catheterization.Clinical Trial RegistrationURL: https://www.chictr.org.cn. Unique identifier: ChiCTR-IPR-15006559.© 2018 American Heart Association, Inc.

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