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Case Reports
Hepatocellular damage following therapeutic intravenous iron sucrose infusion in a child.
- David Michael Wood, Alison H Thomson, Matthew Lawes, Alison Linda Jones, and Paul Ivor Dargan.
- Department of General Medicine, St. George's University of London, London, UK. dwood@sghms.ac.uk
- Ther Drug Monit. 2005 Aug 1; 27 (4): 405-8.
AbstractThe maximum tolerated single dose of intravenous iron infusion and iron pharmacokinetics are not known in children and not clear in adults. The case reported here is of a child given a large dose of intravenous iron sucrose (16 mg/kg) over 3 hours, who subsequently developed features of systemic iron toxicity. A TDM consultant discusses the case in the context of toxicokinetic analysis. Because the maximum tolerated dose and pharmacokinetics of intravenous iron preparations are not known, their use in both adults and children should still be undertaken with caution.
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