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- A S Avdeeva, M V Cherkasova, D A Kusevich, V V Rybakova, A S Artyuhov, E B Dashinimaev, N V Chichasova, and E L Nasonov.
- V.A. Nasonova Scientific and Research Institute of Rheumatology.
- Terapevt Arkh. 2019 May 15; 91 (5): 26-33.
Aimto evaluate the role of laboratory biomarkers in monitoring effectiveness of rituximab (RTM) biosimilar therapy in a total dose of 1200 mg.Materials And Methods20 patients (pts) with rheumatoid arthritis (RA) (18 woman, mean age 61.5(54-66.5) years, mean disease duration 39.5(20-84) months, mean DAS28 5.6(4.9-6.8)) received two intravenous RTM biosimilar infusions (600 mg №2) in combination with DMARDs and glucocorticoids. Laboratory biomarkers were assessed at baseline and weeks 12 and 24 after the first infusion of RTX.ResultsRTM biosimilar induced decreases in DAS28, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) at week 12 and 24, p.
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