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- V I Vorobyev, E G Gemdzhian, E I Dubrovin, E S Nesterova, K D Kaplanov, E M Volodicheva, V A Zherebtsova, and S K Kravchenko.
- Botkin Moscow City Clinical Hospital.
- Terapevt Arkh. 2019 Jul 15; 91 (7): 41-51.
AbstractMantle cell lymphoma (MCL) is aggressive B-cell neoplasm diagnosed predominantly among older men. R-CHOP-like regimens allow to achieve high response rate, but the overall survival (OS) are disappointingly short - 3-4 years. An addition of high - dose cytarabine to the upfront therapy and autoSCT significantly improved outcomes but remain feasible largely for medically fit patients. Based on the activity and good tolerance of gemcitabine - oxaliplatin schemes in relapsed and refractory MCL patients, we developed an alternative first - line course for patients who are not eligible for R-HD-MTX-AraC.
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