• A V Vlasova, V A Isakov, V I Pilipenko, S A Sheveleva, Y M Markova, A S Polyanina, and I V Maev.
• Federal Research Centre of Nutrition, Biotechnology and Food Safety.
• Terapevt Arkh. 2019 Aug 15; 91 (8): 47-51.

AimTo assess the role of Methanobrevibacter smithii in patients with irritable bowel syndrome associated with small intestinal bowel overgrowth.Materials And MethodsSixty - seven patients with IBS according to Rome IV were enrolled into the study in whom hydrogen breath test was performed. Thirty - two healthy subjects with negative breath test was used as a control. All IBS symptoms assessed daily with 5 grade Lykert scale for 7 days, stool was assessed by Brystol stool scale. M. smithii was confirmed in stool samples by PCR.Results And DiscussionIn 67 IBS patients CH4 overproduction was found in 32 (47.7%), H2 overproduction in 31 (46.2%) and normal values in 4 (5.9%) by hydrogen breath test. M. smithii was confirmed by stool PCR in all patients with CH4 overproduction. Severity and prevalence of main clinical features of IBS were similar in both SIBO groups but were significantly higher than in control (p.

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