• Elisabetta Ricottini, Antonio Nenna, Rosetta Melfi, Sara Giannone, Mario Lusini, Sciascio Germano Di GD Unit of Cardiovascular Sciences, Department of Medicine Campus Bio-Medico University of Rome, Via Álvaro del Portillo, 200 - 00128 Rome Italy., Massimo Chello, Gian Paolo Ussia, and Francesco Grigioni.
• Unit of Cardiovascular Sciences, Department of Medicine Campus Bio-Medico University of Rome, Via Álvaro del Portillo, 200 - 00128 Rome Italy. Electronic address: e.ricottini@unicampus.it.
• Eur. J. Intern. Med. 2020 Jul 1; 77: 44-51.

BackgroundThe management of antithrombotic therapy in patients undergoing percutaneous coronary intervention (PCI) with an indication for long-term oral anticoagulant therapy (OAT) is still a matter of debate. We aim to evaluate the safety and the efficacy of dual therapy (DT) compared to triple therapy (TT) in this clinical setting.MethodsA study level meta-analysis and a review of randomized trials selected using PubMed, Embase, EBSCO, Cochrane database of systematic reviews, Web of Science, and abstract from major cardiology congresses. Six randomized trials with 12,156 patients evaluating the strategy of DT vs. TT in patients treated with PCI with indication for long-term OAT were included.ResultsPatients treated with DT demonstrated a 45% relative reduction in the risk of TIMI major bleeding (1.71% vs. 2.99%; OR 0.55, 95% CI 0.41-0.71; P<0.0001) and TIMI minor bleeding compared to TT arm (4.67% vs 7.83%, OR 0.55 95% CI 0.39-0.78, P = 0.0007). All-cause mortality was similar in two arms (3.95% vs 3.77%, P = 0.92), as well as cardiovascular mortality (2.21% vs 2.19%, P = 0.97). DT was associated with a borderline increase of ST (1.02% vs 0.67%, P = 0.07). No significant differences were observed in occurrence of MI and stroke.ConclusionsOur findings suggest that DT is safer than TT with regard to occurrence of major bleeding. DT with a direct oral anticoagulant plus clopidogrel at discharge could be effective in most patients, maintaining aspirin in periprocedural phase and as longer "tailored" treatment for patients at higher ischemic risk.Copyright © 2020 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.

15 keywords...

hide…