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- Toru Arai, Takahiko Kasai, Kazunori Shimizu, Kunimitsu Kawahara, Kanako Katayama, Chikatoshi Sugimoto, Masaki Hirose, Hiroyuki Okamoto, Kazunobu Tachibana, Masanori Akira, and Yoshikazu Inoue.
- Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, Japan.
- Intern. Med. 2020 Oct 15; 59 (20): 2539-2546.
AbstractAutoimmune pulmonary alveolar proteinosis (APAP) is caused by macrophage dysfunction due to anti-granulocyte-macrophage colony-stimulating factor (GM-CSF) autoantibody. We experienced 2 cases of APAP complicated with sarcoidosis in a 42-year-old woman and a 51-year-old man (age at the sarcoidosis diagnosis). APAP preceded sarcoidosis in the woman, and both diseases were diagnosed simultaneously in the man. Sarcoidosis lesions were observed in the lung, skin, and eyes, and the pathological findings of APAP were not marked at the diagnosis of sarcoidosis in either case. Low-grade positive serum anti-GM-CSF autoantibody was suspected to be correlated with the occurrence of sarcoidosis and resolution of APAP.
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