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- Hiroyasu Inoue, Hirofumi Taji, Kentaro Yamada, Chisako Iriyama, Touko Saito, Harumi Kato, Masamitsu Yanada, Kazuhito Yamamoto, and Noriyuki Matsukawa.
- Department of Neurology, Nagoya City East Medical Center, Japan.
- Intern. Med. 2020 Oct 1; 59 (19): 241924212419-2421.
AbstractDasatinib, a tyrosine kinase inhibitor, is commonly used in the treatment of chronic myelogenous leukemia. A rare side effect is peripheral neuropathy. A 54-year-old woman experienced gradually accelerated dysesthesia and hypoesthesia in her extremities, 2 months following treatment with dasatinib. Nerve conduction studies revealed a prolonged conduction velocity with temporal dispersion, indicating demyelinating peripheral neuropathy. After changing dasatinib to nilotinib, both her clinical symptoms and electrophysiological data gradually improved. We herein report the findings of this case with a review of the pertinent literature.
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