• John Yianni, Alexander L Green, Emma McIntosh, Richard G Bittar, Carol Joint, Richard Scott, Ralph Gregory, Peter G Bain, and Tipu Z Aziz.
• Department of Neurosurgery, Radcliffe Infirmary, Woodstock Road, Oxford, UK; University of Oxford, Institute of Health Sciences, UK; Charing Cross Hospital, Fulham Palace Road, London, UK; and Australasian Movement Disorder and Pain Surgery Clinic, Melbourne, Australia.
• Neuromodulation. 2005 Jul 1;8(3):155-61.

AbstractObjectives.  To perform a preliminary cost-utility and cost-benefit of deep brain stimulation (DBS) in the treatment of dystonia, Materials and Methods.  We conducted a prospective study of 26 patients undergoing DBS for the treatment of dystonia. We performed a cost-utility analysis using the Euroquol (EQ-5D) questionnaire. A cost-benefit analysis used the willingness-to-pay principle and costs of treatment were calculated retrospectively in order to calculate the cost-benefit. Results.  We found that the EQ-5D score improved from 29 to 76.2 points after surgery, an incremental utility of 0.47. There was an overall gain of 0.94 quality-adjusted life-years (QALY) with a cost of £33,980 per QALY. Conclusions.  DBS for dystonia, while an expensive treatment, compares favorably to therapies that are commonly used for other conditions.

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