• Robin Ortiz, Chandros Hull Sara S National Institutes of Health and Department of Bioethics, Office of the Scientific Director, National Human Genome Research Institute, Clinical Cent, and Luana Colloca.
• Medicine-Pediatrics Residency Program, Johns Hopkins Hospital, Baltimore, MD and National Institutes of Health, Bethesda, Maryland, USA.
• BMJ Open. 2016 Apr 4; 6 (4): e011012.

ObjectivesTo examine qualitative responses regarding the use of placebo treatments in medical care in a sample of US patients.Survey studies suggest a deliberate clinical use of placebos by physicians, and prior research has found that although most US patients find placebo use acceptable, the rationale for these beliefs is largely unknown.SettingMembers of the Outpatient Clinic at the Kaiser Permanente Northern California interviewed research participants who had been seen for a chronic health problem at least once in the prior 6 months.Participants853 women (61%) and men, white (58%) and non-white participants aged 18-75 years.Primary And Secondary OutcomesQualitative responses on perceptions of placebo use from one-time telephone surveys were analysed for common themes and associations with demographic variables.ResultsPrior results indicated that a majority of respondents felt it acceptable for doctors to recommend placebo treatments. Our study found that a lack of harm (n=291, 46.1%) and potential benefit (n=250, 39.6%) were the most common themes to justify acceptability of placebo use. Responses citing potential benefit were associated with higher education (r=0.787; p<0.024). Of the minority of respondents who judged it never acceptable for doctors to recommend placebo treatments, the most often referenced rationale was obligation of the doctor to do more (n=102, 48.3%). Additional themes emerged around the issue of whether a doctor was transparent about placebo use, including honesty, patient's right to know and power of the mind. Older age was associated with likelihood to cite overall physician, as opposed to treatment, related themes (r=0.753; p<0.002).ConclusionsParticipants seem to appreciate and understand the lack of harm and potential benefit associated with placebo treatments, while valuing the role of the physician and the patient in its implementation.Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

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