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Pulm Pharmacol Ther · Feb 2015
ReviewPleiotropic effects of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors in pulmonary diseases: a comprehensive review.
- Rama K Krishna, Omar Issa, Debjit Saha, Francisco Yuri B Macedo, Barbara Correal, and Orlando Santana.
- Columbia University Division of Cardiology, Mount Sinai Medical Center, Miami Beach, FL, USA.
- Pulm Pharmacol Ther. 2015 Feb 1; 30: 134-40.
AbstractThe 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors (statins) are used extensively in the treatment of hyperlipidemia. They have also demonstrated a secondary benefit in a variety of other disease processes, actions which are known as pleiotropic effects. Review of the current pulmonary literature suggests a potential advantage of statin usage in a variety of pulmonary conditions. Our paper serves as a focused discussion on the pleiotropic effects of statins in the most common pulmonary disorders. Copyright © 2014. Published by Elsevier Ltd.
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