• Dtsch. Med. Wochenschr. · Feb 2020

    Review

    [Vitamin D - A Critical Review of Current Evidence].

    • Carmina Teresa Fuss and Martin Fassnacht.
    • Medizinische Klinik und Poliklinik I, Schwerpunkt Endokrinologie und Diabetologie, Universitätsklinikum Würzburg, Universität Würzburg.
    • Dtsch. Med. Wochenschr. 2020 Feb 1; 145 (3): 135-139.

    AbstractWhile effects of vitamin D on bone metabolism are widely acknowledged, many questions regarding extraskeletal actions of vitamin D have emerged. In-vitro data show the expression of the nuclear vitamin D receptor in a variety of different extraskeletal tissues. However, it's relevance in clinical practice is still unclear. Numerous observational studies suggest that low vitamin D levels might represent a risk factor for several diseases, including cancer, cardiovascular disease and diabetes. Very recently, several randomized controlled trials assessing the effect of vitamin D supplementation on prevention of different diseases have been published with disappointing results. In this review we focus on assessment of vitamin D status, as well as results of currently published randomized controlled trials on vitamin D and disease prevention.© Georg Thieme Verlag KG Stuttgart · New York.

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