• R Shein, J du Toit, M Goeijenbier, C du Toit, and Estelle Verburgh.
• 1Department of Medicine, Division of Clinical Haematology, University of Cape Town, Cape Town, South Africa.
• Neth J Med. 2020 Jul 1; 78 (4): 196-201.

AbstractAcquired haemophilia A is a rare coagulation disorder, which can lead to life-threatening haemorrhages if not identified and treated promptly. It is characterised by the presence of autoantibodies (inhibitors) to factor VIII. Acquired haemophilia A associated with HIV is a rare but well described phenomenon with limited directions to its management. We comparatively describe four patients - two with HIV and two without - that presented with unusual bleeding episodes with a prolonged activated partial thromboplastin time secondary to factor VIII inhibitors. An empiric observation is that the patients with acquired haemophilia A associated with HIV had higher antibody titres at presentation, that required more prolonged immunosuppressive therapy to induce remission.

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