• Onkologie · Jun 1987

    Aplastic anemia: pathogenesis and treatment.

    • A Bacigalupo, G Piaggio, M T Van Lint, O Figari, A Marmont, and M Congiu.
    • Onkologie. 1987 Jun 1; 10 (3): 172-3.

    AbstractTreatment of severe aplastic anemia (SAA) in Europe between 1970 and 1986 is reviewed. 487 patients received an HLA-identical BMT: results are encouraging and currently suggest a 65% survival. However, many patients cannot be offered this procedure because of the absence of an appropriate donor. Forty-five patients were given a non-HLA identical BMT: results are dependent on the degree of mismatch. Immunosuppression (IS) was given to 509 patients: 50% of these survive. Some mechanisms regulating in vitro hematopoiesis are discussed, together with their relevance in the treatment of SAA.

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