• Cristina Bianca Robu, Alexandre Koninckx, Marie-Agnès Docquier, Irina Grosu, Laurent De Kerchove, Stefano Mastrobuoni, and Mona Momeni.
• Department of Anesthesiology, Cliniques Universitaires Saint Luc, Université Catholique de Louvain, Brussels, Belgium.
• J. Cardiothorac. Vasc. Anesth. 2020 Dec 1; 34 (12): 3282-3289.

ObjectivesThe aging brain shows decreased venous oxygenation predominantly in the frontal cortex, which seems sex- dependent. The authors hypothesized that age and sex would influence baseline regional cerebral oxygen saturation (rScO2) measured by the INVOS 5100.DesignSubanalysis of published data.SettingTertiary hospital.ParticipantsA total of 1,616 adults undergoing cardiac interventions.InterventionsNone.Measurements And Main ResultsBaseline rScO2 was recorded at room air and calculated as mean of the left and right rScO2. Patients were divided into 3 groups: 18- to- 49 years: young; 50- to- 74 years: middle-aged; and ≥75 years: elderly. The rScO2 was significantly different in the middle-aged (63 [56-69]) compared with the young participants (67 [59-74]; p < 0.001) and elderly participants (60 [55-66]; p < 0.001]. Women were significantly older compared with men (72 [62-79] v 66 [56-74]; p < 0.001]) and showed lower hemoglobin values (p < 0.001) and lower rScO2 (58 [52-63] v 65 [58-70]; p < 0.001]). Multiple regression analysis revealed age, sex, and hemoglobin as significant determinants of rScO2: 26.665 - (0.030 × age) + (2.581 × hemoglobin) + (2.799 × 0 for female sex).ConclusionsBaseline rScO2, as measured by the INVOS 5100, decreases with advanced age and is lower in women. New definitions of cerebral oxygen desaturation need to be analyzed in future trials that will evaluate neurologic outcome in the aging population or in women.Copyright © 2020 Elsevier Inc. All rights reserved.

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