• Malaria J · Dec 2011

    Review

    Primaquine in vivax malaria: an update and review on management issues.

    • Deepika Fernando, Chaturaka Rodrigo, and Senaka Rajapakse.
    • Department of Parasitology, Faculty of Medicine, University of Colombo, 25, Kynsey Road, Colombo 8, Sri Lanka. ferndeep@gmail.com
    • Malaria J. 2011 Dec 12; 10: 351.

    AbstractPrimaquine was officially licensed as an anti-malarial drug by the FDA in 1952. It has remained the only FDA licensed drug capable of clearing the intra-hepatic schizonts and hypnozoites of Plasmodium vivax. This update and review focuses on five major aspects of primaquine use in treatment of vivax malaria, namely: a) evidence of efficacy of primaquine for its current indications; b) potential hazards of its widespread use, c) critical analysis of reported resistance against primaquine containing regimens; d) evidence for combining primaquine with artemisinins in areas of chloroquine resistance; and e) the potential for replacement of primaquine with newer drugs.

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