• Atencion primaria · Mar 2020

    Observational Study

    [Effectiveness, safety and costs of stroke prevention in non-valvular auricular fibrillation. Study of cohorts matched by Propensity score].

    • Maria Giner-Soriano, Marc Casajuana, Albert Roso-Llorach, Cristina Vedia, and Rosa Morros.
    • Fundació Institut Universitari per a la recerca a l'Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), Barcelona, España; Universitat Autònoma de Barcelona, Bellaterra (Cerdanyola del Vallès), Barcelona, España; Institut Català de la Salut, Departament de Salut, Generalitat de Catalunya, Barcelona, España. Electronic address: mginer@idiapjgol.info.
    • Aten Primaria. 2020 Mar 1; 52 (3): 176184176-184.

    ObjectiveTo analyze the use, effectiveness, safety and costs of stroke prevention in non-valvular atrial fibrillation (AF) in patients initiating treatment with dabigatran or vitamin K antagonists (VKA).SettingPrimary Care (PC) at the Catalan Health Institute (ICS) in Catalonia, during 2011-2013.ParticipantsPatients attended in ICS PC centres with a registered diagnosis of AF who initiate dabigatran or VKA.InterventionsNot applicable MAIN MEASUREMENTS: Number of prescriptions and reimbursements of dabigatran and VKA, incidence of stroke and haemorrhages, incidence of mortatlity, number of sickness leave, and costs associated to all the previous variables.Results14,930 patients were included; 94.6% initiated VKA and 5.4%, dabigatran. Dabigatran patients were younger and with less comorbidity. There were no statistically significant differences between VKA and dabigatran in the risk of stroke, haemorrhages or death. The costs associated to AF management were higher for PC visits in the VKA group, and higher for laboratory and pharmacy in the dabigatran group, although overall costs were not statistically different.ConclusionsMost patients initiated VKA. We found no differences between VKA and dabigatran in the risk of stroke, haemorrhages or mortality.Copyright © 2019 The Authors. Publicado por Elsevier España, S.L.U. All rights reserved.

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