• Ante Punda, Veselin Škrabić, Vesela Torlak, Ivana Gunjača, Vesna Boraska Perica, Ivana Kolčić, Ozren Polašek, Caroline Hayward, Tatijana Zemunik, and Antonela Matana.
• Tatijana Zemunik, Department of Medical Biology, University of Split School of Medicine,Šoltanska 2, 21000 Split, Croatia, tzemunik@mefst.hr.
• Croat. Med. J. 2020 Jul 5; 61 (3): 230-238.

AimTo analyze the association of thyroid function and hormone levels with metabolic syndrome (MetS) and its components.MethodsThis cross-sectional population-based study involved 2183 Croatian individuals with no history of thyroid disease, hypertension, diabetes, and hyperlipidemia. MetS was diagnosed according to the National Cholesterol Education Program's Adult Treatment Panel III criteria.ResultsWe found no association between thyroid function groups and the prevalence of MetS and its components. Clinically hypothyroid participants showed significantly higher triceps skinfold measurements than subclinically hypothyroid and euthyroid participants. Furthermore, clinically hypothyroid participants had higher abdominal skinfold thickness than subclinically hypothyroid participants. Otherwise, suprailiac and abdominal skinfold measurements were higher in the subclinically and clinically hyperthyroid group of participants compared with euthyroid and subclinically hypothyroid participants. A strong positive association of thyroid-stimulating hormone (TSH) and strong negative association of free triiodothyronine (fT3) and free thyroxine (fT4) levels with HOMA-IR and cholesterol levels were found. Furthermore, the fT4 level also showed a strong negative association with HDL and triceps skinfold thickness.ConclusionsThis study supports the standing that TSH, fT3, and fT4 levels are important variables to determine the association of thyroid function with MetS.

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