• Internal medicine journal · Jul 2020

    Observational Study

    An observational study of high- and low-abundance anti-retroviral resistance mutations among treatment-naïve people living with HIV in New Zealand between 2012 and 2017.

    • Nicholas Young, Mark Hobbs, Fahimeh Rahnama, Jinyang Shi, and Simon Briggs.
    • Infectious Diseases Service, Auckland City Hospital, Auckland, New Zealand.
    • Intern Med J. 2020 Jul 1; 50 (7): 872-876.

    AbstractHIV resistance genotyping detects drug resistance mutations (DRMs) in ≥20% of circulating virus within an infected individual (high-abundance DRMs). Deep sequencing also detects DRMs in smaller viral subpopulations (low-abundance DRMs), although these are of uncertain importance. In this retrospective analysis of 292 treatment-naïve patients, high-abundance DRMs were present in 30/292 (10%) patients, but only one (0.3%) had resistance to first-line anti-retrovirals. Low-abundance DRMs were present in 36/247 (15%) patients, but none who received anti-retrovirals for which these were present had virologic failure. These findings demonstrate that starting first-line therapy in treatment-naïve patients need not be delayed while awaiting resistance testing.© 2020 Royal Australasian College of Physicians.

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