• Medicina clinica · Jun 2019

    Review

    Polycystic ovary syndrome in adult women.

    • Andrés E Ortiz-Flores, Manuel Luque-Ramírez, and Héctor F Escobar-Morreale.
    • Grupo de Investigación en Diabetes, Obesidad y Reproducción Humana, Servicio de Endocrinología y Nutrición, Hospital Universitario Ramón y Cajal y Universidad de Alcalá, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid, España.
    • Med Clin (Barc). 2019 Jun 7; 152 (11): 450-457.

    AbstractPolycystic ovary syndrome is the most prevalent endocrine-metabolic pathology in pre-menopausal women. Its etiopathogenesis is complex, multifactorial and heterogeneous, including the interaction of genetic, epigenetic and environmental factors. Androgenic excess constitutes the disease's main physiopathological mechanism and results in reproductive, metabolic and cosmetic alterations which negatively impact these patients' quality of life. The criteria established in the Rotterdam consensus and their correct application form the necessary basis for this syndrome's proper diagnosis. In the absence of an aetiological treatment, the aim is to improve the clinical signs and symptoms derived from hyperandrogenism, ovarian dysfunction and existing metabolic complications, and, therefore, they must be chronic and individualised.Copyright © 2018 Elsevier España, S.L.U. All rights reserved.

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