• World Neurosurg · Nov 2020

    Off-Label Utilization of Syphontrak Catheter for Mechanical Thrombectomy in Acute Stroke.

    • Kaitlyn F Melnick, Jesse Winton, Brian M Corliss, W Christopher Fox, Brian L Hoh, and Adam J Polifka.
    • Department of Neurological Surgery, University of Florida, Gainesville, Florida, USA. Electronic address: Kaitlyn.melnick@neurosurgery.ufl.edu.
    • World Neurosurg. 2020 Nov 1; 143: e106-e111.

    BackgroundIt is not known whether aspiration-specific catheters are necessary for successful mechanical thrombectomy, but if not, off-label use of more versatile catheters could offer significant cost savings over specialized aspiration catheters. The Syphontrak (Depuy Synthes, Raynham, MA, USA) support catheter is designed for introduction of devices into distal neurovasculature but is not specifically indicated for use in mechanical thrombectomy. We sought to compare our experience using this catheter to historical controls to show the non-inferiority of aspiration achieved.MethodsData were collected retrospectively on patients who underwent mechanical thrombectomy using the Syphontrak catheter for aspiration at our institution. Patient demographics, procedure characteristics, and outcome information was recorded. Results were compared to five landmark studies on mechanical thrombectomy: MR CLEAN, ESCAPE, REVASCAT, SWIFT PRIME, and EXTEND-IA.ResultsThere were 63 patients who underwent mechanical thrombectomy for anterior circulation ischemic stroke. Despite significantly older patients and greater time from symptom onset to groin puncture, Thrombolysis in Cerebral Infarction grade 2B or 3 reperfusion was achieved in significantly more patients than in MR CLEAN, ESCAPE, and REVASCAT. Development of symptomatic intracranial hemorrhage occurred in 6.4% of patients, which was not significantly different from MR CLEAN, ESCAPE, REVASCAT, and EXTEND-IA. Mortality was 19.1%, which was not significantly different from any of the trials.ConclusionsThese data support the off-label use of distal intracranial support catheters for this mechanical thrombectomy, which may result in significant cost savings over aspiration-specific catheters, especially in low-volume centers.Copyright © 2020 Elsevier Inc. All rights reserved.

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