• Int. J. Clin. Pract. · Nov 2020

    Observational Study

    Monocentric single-arm study of desmopressin acetate efficacy on nocturnal polyuria in the elderly.

    • Beniamino Palmieri, Tommaso Iannitti, Julio Cesar Morales-Medina, and Maria Vadalà.
    • Department of General Surgery and Surgical Specialties, University of Modena and Reggio Emilia, Modena (MO), Italy.
    • Int. J. Clin. Pract. 2020 Nov 1; 74 (11): e13612.

    Aim Of The StudyWe designed a retrospective, monocentric, observational study to assess the efficacy and short-term side effect profile of desmopressin, a synthetic analogue of antidiuretic hormone, in 42 elderly patients affected by nocturnal polyuria (NP), a subset of nocturia (nocturnal overproduction of urine at night), which is characterised by nocturnal urine volume (NVU) exceeding 33% of the 24-hours total urine output.Methods Used To Conduct The StudyThe subjects had NP and included 25 males, which had benign prostatic hyperplasia (12 out of 25 had been surgically or endoscopically operated) and 15 females that had increased urinary frequency, night-time voiding, loss of bladder control and recurrent bladder infections, due to perineal wall weakness and vaginal or bladder prolapse. Patients recorded the number of voids during waking hours using a digital continuous urine meter. The quality of life (QoL) and efficacy of desmopressin were assessed at baseline and 12 weeks after treatment using the International Consultation on Incontinence Questionnaire Nocturia Quality of Life Module (ICIQ-Nqol) and International Prostate Symptom Score questionnaire (IPPS-Q8). The dosage of desmopressin acetate varied according to the discretion of the physician, usually beginning with one tablet before going to bed at night for 3 months. The dose was increased at 1-week intervals if a reduction in the NVU or night-time frequency was not achieved.Results Of The StudyWe found that desmopressin treatment reduced the nocturnal voided volume (P < .0001), ICIQ-Nqol (P < .0001) and IPPS-Q8 (P < .0001). No significant serum sodium alterations or modifications in serum creatine, potassium, or body weight were observed in all the patients. No adverse effects were observed.Conclusions Drawn From The Study And Clinical ImplicationsOur findings show efficacy of desmopressin in the elderly for NP treatment supporting further clinical trials in larger cohorts of patients.© 2020 John Wiley & Sons Ltd.

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