• Luis Cabezón-Gutiérrez, Sara Custodio-Cabello, Magda Palka-Kotlowska, and Parham Khosravi-Shahi.
• Medical Oncology, Hospital Universitario de Torrejón, Madrid, Spain. Electronic address: lcabezon@torrejonsalud.com.
• J Pain Symptom Manage. 2020 Nov 1; 60 (5): 1047-1054.e1.

IntroductionThis is a review of the evidence from studies of the efficacy and tolerability of topically applied and high-concentration (8%) capsaicin in chemotherapy-induced peripheral neuropathy.MethodsFor this review, we searched EMBASE and MEDLINE to June 20, 2020. The terms used in the search included capsaicin, capsaicin 8% patch, chemotherapy-induced peripheral neuropathy, and cancer.ResultsA total of 98 studies were obtained, but only five were selected for the final analysis, with a total of 95 patients included. Three of the studies are prospective and two retrospective, including less than 30 patients per study. Capsaicin 8% patch provides significant pain relief in chemotherapy-induced peripheral neuropathy in all of them. However, the small number of studies (and patients) evaluated require caution with these results.ConclusionAdditional clinical trials are required to establish the definitive role of the capsaicin patch in the future.Copyright © 2020 American Academy of Hospice and Palliative Medicine. Published by Elsevier Inc. All rights reserved.

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