• Abhimanyu Vasudeva, Shiv Lal Yadav, Srishti Nanda, and Samantak Sahu.
• Department of Physical Medicine and Rehabilitation, All India Institute of Medical Sciences (AIIMS), Gorakhpur.
• Medicine (Baltimore). 2020 Jul 10; 99 (28): e21131.

IntroductionTumor necrosis factor alpha (TNF-α) mediated inflammation has been implicated, in knee osteoarthritis, despite being a predominantly degenerative condition.Patient ConcernsA 56-year old female, a case of left knee pain not responding to conventional conservative strategies.DiagnosisA diagnosis of primary osteoarthritis of the left knee, grade 3 osteoarthritis as per the Kellgren-Lawrence Scale was established.InterventionsShe was administered an intra-articular injection of 10 mg of Adalimumab, a commonly used anti-TNF agent.OutcomesThe patient was evaluated at baseline, 1 month, 3 months, and at 6 months. There was a marked improvement in pain intensity (visual analog scale) and quality of life, despite no objective change on the parameters seen on ultrasound of the knee.ConclusionInjection of adalimumab via the intra-articular route into the knee joint in primary osteoarthritis yields promising results.

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