• Cem Alay, Oya Tekeli, Özge Yanık Odabaş, and Feyza Çalış Karanfil.
• Turk J Med Sci. 2019 Feb 11; 49 (1): 272-278.

Background/AimThis study aimed to evaluate retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) thicknesses using spectral domain optical coherence tomography (SD-OCT) in both unilateral and bilateral exfoliation syndrome (XFS) patientsMaterials And MethodsTwenty-four patients with unilateral XFS, 20 patients with bilateral XFS, and 23 healthy subjects were enrolled in this study. Eyes with XFS were compared with both fellow eyes and age-matched control subject eyes in terms of mean and segmental RNFL thickness and minimum, mean, and segmental GCC thickness.ResultsIn the bilateral XFS group, minimum GCC of the right eye (75.80 ± 11.6 μm) was significantly thinner compared with the right eyes of the control group (81.83 ± 6.6 μm) (P < 0.05). Also, superior RNFL was thinner in the right eye (106.90 ± 16.7 μm) compared with left eye (114.15 ± 18.1 μm) in the bilateral XFS group (P < 0.05). No significant differences in the unilateral XFS group were detected in GCC and RNFL analysis.ConclusionMinimum GCC value may be the first parameter affected in the conversion of XFS to exfoliative glaucoma followed by RNFL changes.

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